Lead contract research division which provides biotransformation,in vitro drug metabolism, in vitro biology and in vitro toxicology supports to CROs, pharmaceutical/biopharmaceutical companies and academic institutions.
She has vast experiences (~10 years) in drug metabolism, pharmacokinetics, metabolite identification of new chemical entities, high resolution mass spectrometry, in vitro metabolism, enzyme kinetics and reversible/irreversible inhibition assays. She is highly experienced in leading DMPK drug discovery projects starting from synthesis to regulatory submission, experienced in leading drug discoveryteams in lead optimization, experienced in providing biotransformation and DMPK support to multiple programs across therapeutic areas in addition to leading multiple drug discovery projects.
Before joining DiponED she worked for Biocon Bristol-Myers Squibb Research Centre from 2008 to 2016 in DMPK department where she worked as Principal Research Investigator and lead several drug discovery projects, lead team in biotransformation and drug metabolism to support in-house and global drug discovery projects. Additionally lead DMPK teams to support in-house and global drug discovery programs in multiple therapeutic areas. In addition to that pursuing innovative research projects which lead to poster or peer reviewed publications. Work as a team leader or member.
List of some important publications:
- Metabolite Identification, Reaction Phenotyping and Retrospective Drug-Drug Interaction Predictions of 17-deacetylnorgestimate, the Active Component of the Oral Contraceptive Norgestimate.Deepak Ahire, Sarmistha Sinha, Barry Brock, RamaswamyIyer,SandhyaMandlekar and Murali Subramanian;Drug MetabDispos 2017 Mar 10. Epub 2017 Mar 10.
- Electrophilicity of pyridazine-3-carbonitrile, pyrimidine-2-carbonitrile, and pyridine-carbonitrile derivatives: a chemical model to describe the formation of thiazoline derivatives in human liver microsomes.Sarmistha Sinha, Deepak Ahire, Santosh Wagh, DibakarMullick, Ramesh Sistla, KumaravelSelvakumar, Janet Caceres Cortes, Siva Prasad Putlur, Sandhya Mandlekar and Benjamin M JohnsonChem Res Toxicol 2014 Dec 2;27(12):2052-61. Epub 2014 Dec 2
- Coupling of an Acyl Migration Prodrug Strategy with Bio-activation To Improve Oral Delivery of the HIV-1 Protease Inhibitor Atazanavir.Subbaiah MAM, Meanwell NA, Kadow JF, Subramani L, Annadurai M, Ramar T, Desai SD, Sinha S, Subramanian M, Mandlekar S, Sridhar S, Padmanabhan S, Bhutani P, Arla R, Jenkins SM, Krystal MR, Wang C, Sarabu R.J Med Chem. 2018 May 10;61(9):4176-4188